摘要Depression is a severe mood disorder characterized by complex suicide mechanisms that in-volve a multitude of psychosocial and biological fac-tors.This paper presents a comprehensive analysis of the psychosocial factors influencing suicidal behavior in de-pression,including social support,life events,depressive symptoms,and personality traits,as well as biological factors such as brain-derived neurotrophic factor(BDNF),erotonin(5-TH)system dysfunction,and hypothalam-ic-pituitary-adrenal(HPA)axis abnormalities.Collec-tively,these factors significantly influence an individual's risk of suicide,with biological factors serving as potential biomarkers for suicidal actions and psychosocial factors underscoring the impact of environmental and individual experiences.Understanding the interaction of these fac-tors is crucial for comprehending and preventing suicidal behavior in depression.Despite considerable progress,current studies have limitations,particularly regarding the unclear interaction mechanisms between psychosocial and biological factors and a predominant focus on adult populations,with insufficient comprehensive studies on adolescents.