摘要目的 探讨DNA修复基因XRCC1 Arg194Trp单核苷酸多态性与脑膜瘤发病风险的关联.方法 运用SNaPshot技术对205例脑膜瘤患者和218例健康对照者的XRCC1多态性Arg194Trp进行检测,比较不同基因型与脑膜瘤患病风险的关系.结果 XRCC1Arg194Trpd的基因型和等位基因频率在病例组和对照组中分布差异无统计学意义,但在＜50岁脑膜瘤组中,C等位基因个体其脑膜瘤发病风险增加( Or=1.594,95％ CI=1.027 ～2.473,P=0.037).XRCC1基因Arg194Trp多态性与脑膜瘤的病理级别和侵袭性差异无统计学意义(P＞0.05).结论 XRCC1基因Arg194Trp遗传变异与脑膜瘤发病风险无关联,但在＜50岁脑膜瘤群体中XRCC1基因C等位基因可能是一个风险因素.

abstractsObjective To investigate the association between the Arg194Trp single nucleotide polymorphism in XRCC1 gene and the susceptibility to meningioma.Methods 205 meningioma patients and 218 healthy controls were collected. The genotypes were analyzed by multiplex SNaPshot methods.Results There was no difference of the distributions of XRCC1 Arg194Trp genotype and allele frequencies between patients and controls.However,in the population with age ＜ 50 years,the individuals with C allele had a higher risk of meningioma ( Or =1.594,95％ CI =1.027 ～ 2.473,P =0.037).There was no difference of the distribution of the XRCC1Arg194Trp genotype frequencies among different patients with different histology grading and with different tumor invasion.Conclusions The XRCC1Arg194Trp polymorphism is not associated with the risk of meningioma.However,XRCC1C allele may be associated with the occurrence of meningioma in early age onset( age ＜ 50 years).