摘要目的 研究非病灶性新皮质癫痫发作间期脑磁图(MEG)与手术切除范围一致性与预后的关系.方法 25例非病灶性新皮质癫痫,术前行发作间期MEG检测以及颅内视频脑电监测(i-VEEG),术后随访1年以上并运用Engel法评价预后.结果 术后总体无发作率(Engel IA) 36％ (9/25)、有效率(Engel Ⅰ级、Ⅱ级)68％(17/25).14例MEG与手术切除范围一致组术后8例无发作,无发作率57％(8/14),有效率71％ (10/14);11例不一致组,术后无发作率9％(1/11),有效率64％(7/11),一致组术后无发作率优于不一致组(P＜0.05).结论 非病灶性新皮质癫痫发作间期MEG与手术切除范围一致与术后无发作率有明确相关性.

abstractsObjective To investigate whether interictal magnetoencephalography (MEG) consistent with surgical range could predict the surgical outcomes in patients with nonlesional refractory neocortical epilepsy (NE).Methods Twenty-five patients with nonlesional NE were studied.All patients had longterm intracranial video-electroencephalography (i-VEEG) monitoring and MEG examinations before surgery.According to the relationship between localization of interictal MEG and surgical range,we divided the participants into two groups,including concordance condition (MEG findings were concordant with surgical range) and discordance condition (MEG findings were discordant with surgical range).Epilepsy surgery was performed to the 25 patient.The surgical outcomes were assessed by neurosurgeons based on over one-year follow-up after surgery using the Engel classification system.Results The total seizurefree (Engel class IA) rate was 36％ (9/25),and the total effective rate was 68％ (17/25).The seizurefree rate of concordance condition was 57％ (8/14),and effective rate was 71％ (10/14).The seizure-free rate of discordance condition was 9％ (1/11),and effective rate was 64％ (7/11).Both the seizure-free rate and effective rate of concordance group were significantly better than those of discordance condition.A statistical difference was found between the seizure-free outcomes of patients with concordance condition and with discordance condition (P ＜ 0.05).Conclusions The study demonstrates that a favorable postsurgical outcome could be prodicted in most patients with concordance of MEG and surgical range.