摘要目的研究不同的肥胖类型对中老年人轻度认知功能损伤(MCI)的影响。 方法以《广州生物库队列研究》为平台，收集第一、二期年龄在50～85岁的19181例广州中老年人的基线资料，通过体格检查、实验室检查结果和详细的问卷调查收集数据，认知能力的测量用10单词延迟记忆得分来评价。分析体重指数、腰臀比、腰围等反映肥胖的测量参数与认知评价得分的相关性。结果(1)除空腹血糖及高血压在正常与异常认知得分人群中无差异外，男女两性在年龄、教育、吸烟状况、喝酒状况、体力活动等生活方式及生理特征上的差异均有统计学意义（P＜0.05）；(2)腰臀比在男女性均显示是MCI的独立危险因素(P＜0.05)。(3)当以认知得分≤3分作为有无轻度认知功能受损进行Logistic回归分析时，腰臀比增大的中老年人群患MCI的危险性均明显增加，女性OR及95％CI为1.57(1.42-1.72)，男性为1.22(1.05-1.41)。 结论 中心性肥胖与轻度认知功能障碍有关联，且这种关系在女性更明显，以腰臀比预测认知功能比其他肥胖测量指数更敏感。

abstractsObjective To explore the association of mild cognitive impairment (MCI) with obesity level in middle and elderly population. Methods A total of 19181 subjects aged 50-85 years were collected in this study from the first and second recruitment phase of the Guangzhou Biobank Cohort Study. The subjects received face-to-face interviews to collect the detailed information on their sociodemographic background, occupational exposures, living environment, lifestyle, family and personal disease histories, and had physical examinations and tests including 12-lead ECG, chest radiograph, and pulmonary function testing. Each subject was screened for a range of fasting biochemical parameters. The cognitive ability was tested with 10-words delayed memory test. The associations between cognition function and anthropometric indices of obesity, including body mass index, waist-to-hip ratio (WHR) and waistline, were evaluated. Results Apart from fast glucose and hypertension in subjects with normal cognition function and abnormal cognition function, some lifestyle and such physiological and biochemical factors as age, education, smoking status, and drinking status were significantly different in both gender (P＜0.05). WHR was the independent risk factor of MCI in both gender (P＜0.05). Logistic regression indicated that high WHR was a risk of MCI in both gender; the greater the WHR, the poorer memory the middle and elderly population; the OR and 95％ CI was 1.57 (1.42-1.72) in female and 1.22(1.05-1.41) in male. Conclusion Centripetal obesity is associated with MCI. WHR is a sensitive indicator influencing the cognitive function in women.