摘要目的 探讨无框架立体定向活检术在颅内多发及深部病变中的应用及操作规范.方法 北京军区总医院及北京市密云医院自2010年1月至2012年10月应用德国BrainLab公司的Vario guide Vector Vision Sky 1.0神经导航系统辅助下行无框架立体定向活检术36例,均获得其病理组织检查确诊. 结果 37例患者中胶质瘤18例(48.64％)(其中胶质母细胞瘤8例)、淋巴瘤4例(10.81％)、神经纤维瘤3例(8.11％)、转移瘤4例(10.81％)、脑膜瘤2例(5.41％)、原发性中枢神经系统外胚层肿瘤1例(2.70％)、炎性病变1例(2.70％)、脑囊虫病1例(2.70％)、结核瘤1例(2.70％)、活检阴性1例(2.70％),病理确诊率97.22％. 结论 对于颅内多发及深部病变,无框架立体定向活检术创伤小,能够有效获得组织行病理学检查,可为后续相关治疗提供重要参考.

abstractsObjective To discuss the application and operation specification of frameless stereotactic biopsy in intracranial multiple and deep lesions.Methods Retrospective analysis of a consecutive series of 36 specimens,collected in our hospitals from January 2010 to October 2012 was performed; the specimens were performed BrainLab Vario guide Vector Vision Sky 1.0 neuro-navigation assisted frameless stereotactic biopsy,and their histopathology was determined.Results Conclusive histopathologic diagnosis was obtained in 35 specimens (97.22％); gliomas were observed in 18 (50.00％),including 8 with glioblastomas; lymphoma in 4 (11.11％),neurofibroma in 3 (8.32％),metastatic tumors in 4 (11.11％),meningiomas in 2 (5.56％),primary central nervous system ectodermal tumor in 1 (2.78 ％),inflammatory lesion in 1 (2.78％),cerebral cysticercosis in 1 (2.78％),tuberculosis tumor in 1 (2.78％) and negative biopsy in 1 (2.78％); no serious complications followed by stereotactic biopsy were noted.Conclusion In the intracranial multiple and deep lesions,frameless stereotactic biopsy is safe and minimally invasive; through it,the pathology can be obtained,which is significant for the subsequent treatments.