摘要目的 应用基于体素分析的扩散张量成像研究伤害避免人格与脑各向异性分数之间的相关性,以探讨人格的脑白质微观结构基础. 方法 自2010年11月至2011年4月,通过广告招募333名右利手受试者参加研究(受试者为天津医科大学在校学生及周围社区人员).研究内容为填写三维人格问卷及Beck抑郁问卷,并行三维MRI及扩散张量成像扫描.所有扩散张量成像数据行预处理后,使用SPM8软件,以年龄和抑郁评分为控制变量,对整体数据进行偏相关分析,研究脑各向异性分数值与伤害避免人格评分的相关性[以簇体积大于30个体素,且P＜0.001(未矫正)为差异有统计学意义的阈值]. 结果 伤害避免评分与中脑、脑桥、左侧海马旁回、颞下回、颞中回、右侧苍白球、双侧顶上小叶各向异性分数值呈正相关；与左侧壳核、丘脑、双侧楔前叶各向异性分数值呈负相关. 结论 伤害避免与特定脑结构的各向异性分数值存在相关性.

abstractsObjective To study the correlation between harm avoidance(HA) personality and fractional anisotropy (FA) with voxel-based analysis (VBA) of diffusion tensor imaging (DTI),and to explore the microstructure of white matter of personality.Methods A total of 333 healthy right handed volunteers,recruited from November 2010 to April 2011,completed the Chinese version of three-dimensional personality questionnaire (TPQ) and Beck depression inventory (BDI),and after that,3D MRI and DTI scan were performed.All preprocessed DTI data were analyzed with SPM8 software in partial correlation analysis by using age and depression scores as controlled variables.The correlation between HA and FA was investigated (a voxel significance thresholdP＜0.001 and a cluster extent threshold of 30 voxels).Results HA was positively correlated with FA of the midbrain,pons,left parahippocampal gyrus,inferior temporal gyrus,middle temporal gyrus,right globus pallidus and bilateral superior parietal lobule,and was negatively correlated with FA of the leg putamen,thalamus and bilateral precuneus.Conclusion FA of the special brain areas is associated with harm avoidance personality dimension.