摘要目的 探讨血压变异与不同类型脑卒中患者的相关性. 方法 选择自2013年1月1日至2015年12月31日在日照市人民医院神经内科住院且行24 h动态血压监测的脑卒中患者203例.根据CT/MRI扫描结果,将所有患者分为缺血性脑卒中125例和出血性脑卒中78例,并同期入选在该院查体的健康人群66例.对所有受试者行24 h动态血压监测,记录所有数据并比较3组受试者夜间血压下降率(BPF)、血压晨峰(MBPS)、标准差(SD)、加权标准差及变异系数等参数,明确脑卒中的影响因素. 结果 缺血性脑卒中组与出血性脑卒中组收缩压(sBP)晨峰明显高于对照组,且缺血性脑卒中组SBP晨峰低于出血性脑卒中组,差异均有统计学意义(P＜0.05).缺血性脑卒中组与出血性脑卒中组SBP加权标准差、变异系数及BPF与对照组相比,差异有统计学意义(P＜0.05).出血性脑卒中舒张压变异系数及BPF与对照组相比,差异有统计学意义(P＜0.05).多元Logistic回归分析显示:高密度脂蛋白、夜间平均收缩压(nSBP)、SBP加权标准差、SBP变异系数是缺血脑卒中的影响因素;吸烟、nSBP、SBP加权标准差、MBPS、SBP变异系数是出血性脑卒中的影响因素. 结论 短时血压变异与缺血性脑卒中和出血性脑卒中均相关.

abstractsObjective To explore the relationship between blood pressure variability and different types of stroke.Methods One hundred and twenty-five ischemic stroke subjects,78 hemorrhagic stroke patients and 66 non-stroke individuals,collected in our hospital from January 1,2013 to December 31,2015,were enrolled according to the inclusion and exclusion criteria.All indicators of blood pressure variability were calculated from 24 h ambulatory blood pressure,including nighttime blood pressure fall (BPF),moming surge in blood pressure (MBPS),standard deviation (SD),weighted SD (wSD),and coefficient of variation (CV).Results As compared with non-stroke subjects,ischemic and hemorrhagic stroke individuals had significantly increased systolic MBPS (P＜0.05),and the systolic MBPS of ischemic stroke group was significantly lower than those of hemorrhagic stroke group (P＜0.05).CV,wSD and BPF of systolic blood pressure (SBP) in the ischemic and hemorrhagic groups were significantly higher than those in the non-stroke subjects (P＜0.05);CV and SBPF of diastolic blood pressure in hemorrhagic group were significantly different as compared those in the non-stroke subjects (P＜0.05).The factors which were significantly associated with ischemic stroke in Logistic regression,included high-density lipoprotein,nighttime SBP,wSD of SBP,CV of SBP,while smoking,nighttime SBP,wSD of SBP,MBPS,and CV of SBP were observed as important influence factors for hemorrhagic stoke patients.Conclusion Whether ischemic stroke,or hemorrhagic stroke are associated with short-term blood pressure variability.