摘要炎症反应是引起脑出血后继发性脑损伤的重要原因,而内质网应激是介导脑出血后炎症反应的重要因素,它可以激活一系列炎症相关信号通路,从而调控神经细胞存活或死亡,影响神经功能修复.因此,深入了解脑出血后内质网应激与炎症反应之间的相互联系及其信号通路,可为脑出血的治疗提供新的策略及依据.笔者现围绕脑出血后内质网应激与炎症反应之间的关系及其在脑出血中的重要作用展开综述.

abstractsEndoplasmic reticulum (ER) stress is an important mediator causing inflammatory response, which additionally exerts secondary injury after intracerebral hemorrhage (ICH) to influence brain function recovery through a variety of cell signaling and response, to regulate neural cells survival or death. Therefore, further understanding about the relation between ER stress and inflammatory response as well as the signal transduction pathway can provide new therapeutic strategies and evidence for treatment of ICH. The present review summarizes the process of ER stress activation and the relation between inflammatory response and ER stress activation after ICH.