摘要癫痫是一种中枢神经系统常见疾病，约25%的患者为育龄期女性。女性癫痫患者妊娠期服用抗癫痫药物(AEDs)可能导致胎儿畸形、子代神经发育障碍等长期不良影响，且多与药物剂量和(或)联合用药相关。对育龄期女性癫痫患者进行孕前咨询、调整治疗方案、计划怀孕和孕前补充叶酸等可能会对胎儿发育及子代神经发育有一定帮助。笔者现围绕宫内暴露于AEDs对胎儿发育及子代神经发育的影响及其机制、应对策略等进行综述，以期为临床医生全面了解AEDs与胎儿畸形、子代神经发育障碍之间的关联提供参考，从而减少临床上宫内AEDs暴露对胎儿的影响。

abstractsEpilepsy is a common disease of the central nervous system, and about 25% of patients are women of childbearing age. Exposure to antiepileptic drugs (AEDs) during pregnancy in epileptic women may cause fetal malformations, progeny neurodevelopmental disorder and other long-term adverse effects, mostly related to drug dosages and combinations medication. Preconception counseling, adjustment therapeutic regimen, pregnancy planning and supplementing folic acid before pregnancy maybe help for fetal development and progeny neurodevelopment. This review focuses on the effect of intrauterine exposure to AEDs on fetal malformation and neural development in offspring, as well as its mechanism and coping strategies, in order to provide a reference for clinicians to fully understand the relations of AEDs with fetal malformation and progeny neurodevelopmental disorder, so as to reduce the clinical effect of intrauterine AEDs exposure on the fetus.