摘要近年来，许多研究发现血管源性脑白质高信号(WMH)与认知障碍密切相关，这反映了白质宏观结构损伤对认知的负面影响，而弥散张量成像(DTI)可以通过不同的影像学参数量化白质微结构损伤，对认知障碍的早期诊断、进展风险和疗效评估有重要价值。此外，在DTI基础上联合图论的分析方法得到的脑结构网络相关参数也被认为与WMH认知障碍有关。故本文围绕DTI衍生参数、脑结构网络参数的最新进展以及其与WMH认知障碍的关联综述如下。

abstractsIn recent years, many studies have found that white matter hyperintensity (WMH) of presumed vascular origin is closely related to cognitive impairment, which reflects the negative effects of white matter macrostructure damage on cognition, while diffusion tensor imaging (DTI) can quantify white matter microstructure damage through different imaging parameters. A variety of DTI parameters are associated with cognitive impairment in WMH, and are of great value in early diagnosis, evaluation of progress risk and efficacy of cognitive impairment. On the basis of DTI, the relevant parameters of brain structural network obtained by joint the graph theory analysis method are also considered to be related to the cognitive impairment with WMH. This paper reviews the latest progress of DTI derived parameters, brain structural network parameters and their relations with WMH cognitive impairment.