摘要目的:探讨参肽茶多酚对客观认知正常的健康中老年人的记忆功能的干预效果及其潜在机制。方法:采用随机、双盲及安慰剂对照的前瞻性试验设计，对首都医科大学宣武医院神经内科自2019年4月至12月通过广告招募的240例客观认知正常的健康中老年人，采用随机数字表法分为试验组( n=120)与对照组( n=120)，分别给予参肽茶多酚或安慰剂胶囊口服(持续90 d，2次/d，2粒/次)干预，并于干预前后采集各受试者的神经心理学量表评分及近红外脑成像数据，自干预前基线期数据收集开始至干预后随访期数据收集结束的平均时间控制在6个月内。 结果:与干预前比较，试验组干预后的听觉词语学习测验(华山版)中的延迟回忆、再认回忆评分及波士顿命名评分、蒙特利尔认知评估量表(基础版)评分均明显增高，汉密尔顿焦虑量表评分、形状连线测验A评分和快速眼动睡眠期行为障碍筛查量表评分均明显降低，差异均有统计学意义( P<0.05)；而对照组干预后仅听觉词语学习测验(华山版)中的延迟回忆评分明显升高，差异有统计学意义( P<0.05)。试验组共有23对干预前后脑功能连接差值明显高于对照组，差异均有统计学意义( P<0.05)，主要涉及额顶控制网络内的功能连接及其与默认网络、体感运动网络、背侧注意网络和视觉网络间的功能连接，以及默认网络与体感运动网络间的功能连接。 结论:在客观认知正常的健康中老年人中，参肽茶多酚可能通过影响脑区间的功能连接进一步改善其记忆、语言和执行等认知功能及焦虑情绪、睡眠状态。

abstractsObjective:To investigate the effect of Shentai Tea Polyphenols on memory and its underlying mechanism in healthy elderly adults.Methods:According to the randomized, double blind and placebo-controlled prospective experimental design, 240 healthy middle-aged or elderly subjects with normal objective cognition were recruited in our hospital from April to December 2019 through advertising, and they were randomly divided into an experimental group ( n=120) and a control group ( n=120). Oral administration of Shentai Tea Polyphenols or placebo capsules (lasting for 90 d, 2 times/d, 2 capsules/time) was given to subjects in the two groups. The neuropsychological scale scores and near-infrared brain imaging data of all subjects were collected before and after intervention, and the mean time from baseline data collection before intervention to follow-up data collection after medication was controlled within 6 months. Results:In patients from the experimental group, as compared with those before intervention, scores of delayed recall and recognition memory in the auditory verbal learning test (Huashan version) and Boston naming test, scores of Montreal cognitive assessment scale (basis version) were significantly higher, and scores of Hamilton anxiety scale, shape trails test A and rapid-eye-movement sleep behavior disorder screening questionnaire were significantly lower after intervention ( P<0.05); however, only scores of delayed recall in the auditory verbal learning test (Huashan version) were significantly increased in the control group ( P<0.05). A total of 23 pairs of differences of brain function connection before and after intervention in the experimental group were significantly higher than those in the control group ( P<0.05), mainly involving the function connection of forehead peak network (FPN), and function connection of FPN-default network, function connection of FPN-somatosensory movement network, function connection of FPN-dorsal attention network and function connection of FPN-visual network, as well as the function connection of default network and somatosensory movement network. Conclusion:Shentai Tea Polyphenols can improve cognitive performances including memory, language and executive function, anxiety mood and sleep quality in healthy middle aged or elderly subjects by affecting the functional connections of the networks in the brain.