摘要AD是构成全球重大社会问题和经济威胁的中枢神经系统退行性疾病之一，早期诊断和干预是其防治的关键。传统的以临床经验和生物学标志物为依据的AD诊断体系存在诸多局限。目前，随着人工智能、5G网络等技术的迅猛发展，一种全新的基于可穿戴设备的"数字化生物标志物"诊断体系正在构建。本文现全面阐述用于记忆、视空间、言语、执行功能等不同认知相关信号捕捉的可穿戴设备在AD"数字化生物标志物"诊断体系构建中的研究进展，并展望其在未来AD诊断及防治中的应用前景。

abstractsAlzheimer's disease (AD) is one kind of degenerative diseases of the central nervous system, constituting a major social problem and economic threat around the world. Early diagnosis and intervention are the keys to its prevention and treatment. The traditional diagnosis system based on clinical experience and biomarkers has many limitations. A completely new "digital biomarkers" diagnostic system based on wearable devices is being constructed with the rapid development on artificial intelligence, 5G network and other technologies. This article will comprehensively describe the research progress on wearable devices which used to capture different cognitive-related signals such as memory, visual space, speech, executive functions in the construction of AD "digital biomarkers" diagnosis system, and forecast its application prospect in the future diagnosis, prevention and treatment of AD.