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颅内富血供肿瘤的术前介入栓塞治疗

Preoperative interventional embolization for intracranial hypervascular tumors

摘要目的:探讨供血动脉介入栓塞对于颅内富血供肿瘤的治疗价值。方法:回顾性分析复旦大学附属华山医院神经外科自2019年3月至2022年8月行开颅手术切除前供血动脉介入栓塞的45例颅内富血供肿瘤患者资料,总结其肿瘤影像学特点、病理类型、术前栓塞指征、栓塞效果和栓塞相关并发症,从而评估术前介入栓塞治疗的安全性和有效性。结果:45例患者中21例为血管母细胞瘤,15例为脑膜瘤,5例为血管外皮瘤,4例为颈静脉球瘤。介入栓塞技术成功率达97.8%(44/45),其中1例脑膜中动脉过于迂曲,栓塞微导管无法到位。介入栓塞成功病例中,41例患者采用液体栓塞剂Onyx,3例采用液体栓塞剂NBCA。完全栓塞7例,大部栓塞26例,部分栓塞11例。出现栓塞相关并发症共4例,其中2例脑膜中动脉破裂出血,1例Marathon微导管无法拔出,1例功能型颈静脉球瘤术中发生嗜铬细胞瘤危象。该4例患者术中均及时处理,未造成严重后果。结论:对于颅内富血供肿瘤,术前介入栓塞安全有效,但需严格掌握介入手术指征并选择合理的栓塞方式和栓塞材料。

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abstractsObjective:To investigate the therapeutic value of interventional embolization on feeding artery in intracranial hypervascular tumors.Methods:Forty-five patients with intracranial hypervascular tumors, admitted to and accepted interventional embolization of the feeding artery before craniotomy in Department of Neurosurgery, Huashan Hospital Affiliated to Fudan University from March 2019 to August 2022, were chosen; a retrospective analysis was performed on the clinical data of these patients. The imaging characteristics, pathological types, preoperative embolization indications, embolization effects and embolism-related complications were summarized to evaluate the safety and effecacy of preoperative interventional embolization.Results:Among the 45 patients, 21 patients had hemangioblastomas, 15 had meningiomas, 5 had hemangiopericytomas, and 4 had glomus jugular tumors. The technical success rate of interventional embolization was 97.8% (44/45); in this frustrated case, the middle meningeal artery was too circuitous for microcatheter to pass. Among the successful ones, 41 patients used liquid embolism agent onyx and 3 patients applied liquid embolism agent NBCA. Seven, 26 and the rest 11 patients achieved complete embolization, sub-total embolization and partial embolization, respectively. Four patients had embolism-related complications, including 2 with rupture of middle meningeal arteries, 1 with Marathon catheter failed to be pulled out, and 1 with functional glomus jugular tumor having pheochromocytoma crisis; these 4 patients were treated timely without serious complications.Conclusion:For intracranial hypervascular tumors, preoperative interventional embolization is safe and effective; it is necessary to master embolization indications and select appropriate embolization methods and materials.

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中华神经医学杂志

中华神经医学杂志

2023年22卷2期

135-141页

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