摘要TDP-43病理蛋白在阿尔茨海默病（AD）中的重要作用正被逐歩揭示。近半数AD患者TDP-43病理蛋白阳性，并与患者海马萎缩及认知功能障碍严重程度呈正相关，提示TDP-43病理蛋白可能是AD的重要诊疗靶点，及时评估AD患者脑内TDP-43病理蛋白情况，对AD的诊断、药物研发及治疗将产生巨大影响。本文就TDP-43病理蛋白在AD中的病理表现，以及以TDP-43病理蛋白为靶点对AD进行诊疗方面的研究进展进行综述。

abstractsThe important role of TDP-43 proteinopathy in Alzheimer's disease (AD) has been gradually revealed. High proportion of AD patients have TDP-43 proteinopathy on their postmortem diagnosis. Patients with TDP-43 proteinopathy show more sever hippocampal atrophy and cognitive dysfunction, suggesting that TDP-43 proteinopathy can serve as an important target in AD diagnosis and treatment. Evaluation of TDP-43 proteinopathy in vivo would hold great promise in AD diagnosis, drug development and treatment. In this review, we describe the pathological characteristics of TDP-43 proteinopathy in AD, and summarize the recent progress of TDP-43 proteinopathy in the diagnosis and treatment of AD.