摘要原位诱导修复再生是一个多学科交叉的研究领域，对大面积深度烧伤创面以及糖尿病性皮肤溃疡等慢性创面的治疗均具有重要的潜在价值。近年来研究者对原位成形可注射水凝胶，即在创面局部应用可在生理条件下自发凝胶化的水凝胶类生物材料进行了探索。该类生物材料含有细胞外基质成分，可以根据需求添加促进创面修复的细胞，还能作为生长因子等活性肽的控释载体，模拟创面局部微环境，从而诱导修复再生。本文对原位成形可注射水凝胶的原位凝胶化特性及促进创面修复再生的作用进行综述，包括其材料种类、作用机制、优势及存在的问题等。

abstractsResearch of in-situ induced repair and regeneration is a multi- and inter-disciplinary field, which is of important potentials in the treatment of both large-area deep burns and chronic wounds such as diabetic skin ulcers. In-situ forming injectable hydrogels which are hydrogel-like biomaterials that can spontaneously gelatinize in physiological condition when applied in local wounds have been explored in recent years. This kind of biomaterials contain extracellular matrix, in which cells promoting wound repairing can be added if required, and can work as release-controlled carriers for active peptides such as growth factors to simulate local wound microenvironment and induce the repair and regeneration. Herein, characteristics and function of promoting wound repair and regeneration about in-situ forming injectable hydrogels were reviewed, including material types and their relevant working mechanisms, advantages, existing problems, etc.