摘要目的:探讨Meek皮片移植联合富血小板血浆（PRP）修复大面积深度烧伤创面的临床效果。方法:该研究为回顾性观察性研究。2018年8月—2023年8月，空军军医大学第一附属医院收治44例符合入选标准的患者，其中男23例、女21例，年龄22~62岁，烧伤总面积30%~80%体表总面积，四肢或躯干部位为深Ⅱ~Ⅲ度烧伤。根据四肢或躯干深度烧伤部位治疗过程，将患者分为观察组（21例）和对照组（23例），观察组患者接受Meek皮片移植联合PRP同期治疗，对照组患者接受单纯Meek皮片移植。术后10 d，观测患者Meek皮片成活情况。术后14 d，观测患者术区创面愈合率。统计术后创面愈合时间、创面分泌物标本细菌培养阳性率。结果:术后10 d，观察组患者植皮区较为干燥，Meek皮片与创基贴合紧密、色泽多红润，皮片成活率为（89±4）%；对照组患者植皮区部分Meek皮片脱落，残余创面呈散在不规则地图状，伴有不同程度脓性分泌物，皮片成活率为（79±6）%，明显低于观察组（ t=6.72， P<0.05）。术后14 d，观察组中19例患者术区创面完全愈合，另2例患者残余细小创面经换药后延期1周愈合；对照组中12例患者术区创面完全愈合，6例患者术区创面经补充邮票皮移植术后愈合，5例患者术区创面经常规换药后延期愈合，创面愈合率明显低于观察组（ P<0.05）。术后，观察组患者术区创面愈合时间为（13.3±1.6）d，明显短于对照组的（16.4±3.5）d， t=3.72， P<0.05；观察组和对照组患者创面分泌物标本细菌培养阳性率比较，差异无统计学意义（ P>0.05）。 结论:对于大面积深度烧伤创面，采用Meek皮片移植联合自体PRP较单纯Meek皮片移植治疗，可促进皮片成活，加快皮片扩展融合，缩短创面愈合时间，从而提高治疗效果。

abstractsObjective:To investigate the clinical effects of Meek skin grafting combined with platelet-rich plasma (PRP) in repairing of extensive deep burn wounds.Methods:This study was a retrospective observational study. From August 2018 to August 2023, 44 patients who met the inclusion criteria were admitted to the First Affiliated Hospital of Air Force Medical University, including 23 males and 21 females. Their age ranged from 22 to 62 years and the total burn area was 30%-80% total body surface area, the burns on limbs or torso were deep partial-thickness to full-thickness. According to the treatment process of deep burns on the limbs or torso, the patients were divided into observation group (21 cases) and control group (23 cases). patients in observation group were treated with Meek skin grafting combined with PRP at the same time, while patients in control group were treated with Meek skin grafting alone. The survival of Meek skin grafts was observed on the 10 th day after operation. The wound healing rate in the operation area of patients was observed on the 14 th day after operation. The postoperative wound healing time and positive rate of bacterial culture of wound secretion specimens were recorded. Results:On the 10 th day after operation, the skin grafting area of patients in observation group were dry, and the skin grafts adhered closely to the wound base with ruddy color, with a survival rate of (89±4)%; whereas in control group, some of Meek skin grafts fell off in the skin graft area, and the residual wounds were scattered in irregular map shape, accompanied by purulent secretions. The survival rate of skin grafts was (79±6)%, which was significantly lower than that in observation group ( t=6.72, P<0.05). On the 14 th day after operation, 19 patients in observation group had complete wound healing in the operation area, and the other 2 patients had small residual wounds, which healed after 1 week delay through dressing changes; in control group, the wounds in 12 patients healed completely, the wounds in 6 patients healed after supplementary stamp skin grafting, and the wounds in 5 patients healed with delay after routine dressing changes. The wound healing rate was significantly lower than that in observation group ( P<0.05). After operation, the wound healing time of the operation area of patients in observation group was (13.3±1.6) days, which was significantly shorter than (16.4±3.5) days in control group ( t=3.72, P<0.05); there was no statistically significant difference in the positive rate of bacterial culture of wound secretion specimens between observation group and control group after operation ( P>0.05). Conclusions:Compared with Meek skin grafting alone, Meek skin grafting combined with autologous PRP can promote the survival of skin grafts, accelerate the expansion and fusion of skin grafts, and shorten the wound healing time, thereby improving the therapeutic effect in the repairing of extensive deep burn wounds.