摘要目的 采用Micro-Cr扫描采集人类拇指末节指骨三维微观数据并使用三维立体打印机,建立三维指骨支架材料模型,对仿生化、智能化组织工程支架材料的体外构建进行初步探讨.方法 对成年男性新鲜拇指末节标本进行Micro-CT扫描,所得的原始DICOM数据为基础,通过Mimics软件三维处理得到宏观及微观仿生的三维打印STL文件,并通过三维打印机打印出指骨支架三维模型.结果 采用Micro-CT扫描得到的数据用Mimics三维医学处理软件处理后,可直接用三维立体打印机快速成型构建仿生化、数字化组织工程指骨支架材料.结论 基于Micro- CT及三维打印机的仿生化、智能化组织工程骨建模技术对治疗指骨毁损伤有重要的临床意义,且有良好的应用前景.

abstractsObjective To prepare biomimetic,intelligent scaffold for tissue engineering of thumb distal phalanx using gathered three-dimensional (3D) data. Methods Distal phalanxes from fresh adult cadaver thumbs were subject to micro -CT scanning.The DICOM data from micro-CT scans were processed using Mimics software to form the macro and micro biomimetic 3D printing STL file.3D printer was then used to prim out a scaffold of a phalanx. Results The data acquired by micro-CT scanning can be rapidly prototyped after being edited with Mimics and directly used by 3D printing system to construet a biomimetic,intelligent scaffold.Conclusion Biomimetic,intelligent scaffold based on micro-CT and 3D printing has clinical significance in reconstruction of destructed thumbs.