摘要目的 观察复方丹参滴丸对断指再植术后患者活化部分凝血酶时间(APTT)的影响.方法 选取符合纳入标准的断指再植患者50例,随机分成2组各25例,术后抗凝血治疗.实验组口服复方丹参滴丸,对照组静脉滴注肝素钠.观察2组APTT,再植成活率,血管危象发生率.结果 实验组25例,存活25例,再植成活率100％;对照组25例,存活25例,成活率100％.实验组25例,发生血管危象1例,发生率4％;对照组25例,无血管危象发生,发生率0％.术后第3天实验组APTT与对照组比较,差异有统计学意义(t=16.506,P=0.000＜0.05),术后第10天两组APTT比较,差异有统计学意义(t=12.300,P=0.000＜0.05).结论 复方丹参滴丸能较少地影响APTT,可以避免再植术后应用肝素钠导致的APPT延长,可在一定程度上作为肝素钠的替代药物应用于断指再植术后抗凝血治疗,但仍需要大样本的研究证实.

abstractsObjective To observe the effect of compound Danshen dropping pills on the activated partial thromboplastin time (APTT) of the patients after finger replantation.Methods A total of 50 cases with finger replantation were randomly divided into two groups with 25 in each:experimental group and control group.After the replantation,anticoagulant therapy was conducted in experimental group with oral compound Danshen dropping pills and in control group with intravenous heparin sodium.APTT,survival rate and vascular crisis incidence rate were compared between two groups.Results All the replanted fingers from two groups survived with the survival rate being 100％.One case from experimental group had vascular crisis with the incidence rate being 4％ and no vascular crisis occurred in control group.At 3 days after the replantation,the APTT of control group was longer than that of experimental group (t=16.506,P=0.000＜0.05).At 10 days after the replantation,the APTT of control group was still longer than that of experimental group (t=12.300,P=0.000＜0.05).Conclusion The compound Danshen dropping pills can exert less effect on APTT in order to avoid the APTT extension induced by heparin sodium after replantation.To some extent,it can be used as alternative medicine of heparin sodium for anticoagulant therapy after replantation,but large sample studies are still necessary to confirm the research outcome.