摘要目的探讨丙型肝炎病毒核心抗原（ HCV-cAg）酶联免疫检测（ ELISA）在丙型肝炎早期诊断中的应用价值。方法83例抗-HCV阳性、500例ALT异常但抗-HCV阴性血清同时进行HCV-cAg ELISA和HCV RT-PCR。结果83例抗-HCV阳性血清中HCV-cAg和HCV RNA阳性分别为33例和36例，其中32例共阳性；500例ALT异常但抗-HCV阴性的血清中有3例HCV-cAg和HCV RNA同为阳性。抗-HCV阳性和阴性血清HCV-cAg和HCV RNA检测结果符合率分别为94.0％和100％。结论 HCV-cAg ELISA敏感性与HCV RT-PCR类似，能够有效缩短窗口期，操作简便，费用低廉，在丙型肝炎早期诊断中具有很好的前景。

abstractsObjective To evaluate the clinically applied valve of HCV core antigen enzyme-linked immunosorbent assay ( HCV-cAg ELISA) for early diagnosis of hepatitis C.Methods Both HCV RNA and HCV-cAg ELISA were used to detect 83 cases of anti-HCV positive serum samples and 500 cases of anti-HCV negative but ALT abnormal serum samples.Results In the 83 cases of anti-HCV positive serum samples, 33 cases were detectable for HCV-cAg while 36 cases were detectable for HCV RNA, in which 32 cases were double positive for both HCV-cAg and HCV-RNA.In the 500 cases of anti-HCV negative but ALT abnormal serum sample, only 3 cases were detectable for both HCV-cAg and HCV RNA. The coincidence rates of the two methods for detecting the anti-HCV positive serum samples and anti-HCV negative but ALT abnormal serum samples were 94.0% and 100%, respectively.Conclusion The sensitivity and specificity of HCV-cAg ELISA is similar to that of HCV RT-PCR.The HCV-cAg ELISA has many advantages such as window-phase,decurtation, convenience and lower cost, which enable the assay a good clinically applied prospects for early diagnosis of hepatitis B.