摘要目的 通过两种方法 构建兔VX-2移植性原位肾癌模型,并对其进行评估.方法 将30只新西兰白兔随机分2组,每组15只.A组采用开放手术下VX-2肿瘤组织块包埋种植法建模;B组采用经皮超声引导下VX-2肿瘤组织悬液经皮注射种植法建模,通过连续的CT及病理观察与评估模型的稳定性.结果　两组建模均成功.A组模型所有肿瘤均为单发,呈外生性肿瘤,形状规则.B组模型有2只出现腹壁种植,占13.3%,肾脏肿瘤生长多形状不规则,常较早突破包膜,沿入针处向肾外生长,部分肾脏肿瘤为完全内生型肿瘤,早期即侵犯集合系统.结论　采用开放手术下VX-2肿瘤组织块包埋种植法建模,肿瘤具有单发、呈外生性生长、形状规则等特点,有利于肾癌如射频消融等微创治疗的实验研究,为其提供稳定的动物模型.

abstractsObjective To establish a model of implanted renal carcinoma in situ and compare the advantages and disadvantages of two methods to establish the rabbit VX-2 renal carcinoma model. Methods Thirty purebred New Zealand white rabbits were divided evenly and randomly into two groups and the VX-2renal carcinoma model was established. In group A tumor block was implanted by open operation, and in group B VX-2 tumor tissue suspension was subcutaneously injected under the guide of ultrasound. Results Tumor was successfully implanted in both groups. In group A, tumor grew in proper shapes and positions. In group B there were two abdominal implanting examples ( 13. 3% ), and tumor usually grew outside the kidney throughout the pin hole or even encroached on the kidney collecting system in the first two weeks. Conclusion The tumor tissue block implanting can be used as a better method than the tumor tissue suspension injection in modeling the VX-2 renal carcinoma in situ.