摘要目的 建立兔的股骨远端中心型骺板缺损后骨桥切除的动物模型,并对骨桥切除后的效果进行评价.方法 选用日本大耳白兔10只,观察β-TCP与骨组织相容性及对骨桥生长影响.另取30只日本大耳白兔,分为A组(β -TCP标记+骨桥切除+脂肪填塞)、B组(β-TCP标记+骨桥切除)、C组(单纯缺损),每组10只,评价β -TCP标记,导针引导的方法切除骨桥的手术效果.结果 β-TCP置入后组织相容性良好,对骺板缺损后股骨畸形的程度没有影响(P＞0.05)；标记侧股骨长度(85.29 ±4.73) mm,外翻角度(12.35 ±2.53)°；未标记侧分别为(84.34 ±2.76) mm,(12.52±3.26)°.通过β-TCP标记,导针引导的方法可完整切除骨桥.运用脂肪筋膜瓣填塞骨桥切除后的缺损,可减轻股骨畸形的程度(P＜0.01).A、B、C组的股骨短缩程度分别为(4.20±1.36)、(10.26±3.31)、(6.52±1.62) mm；外翻角的差异分别为(12.00±2.11)°、(23.47±4.06)°、(18.38±10.65)°.结论 通过β-TCP标记,导针引导的方法可建立兔股骨远端中心型骺板缺损后骨桥切除的标准动物模型.

abstractsObjective To build the animal model of bone bridge resection in rabbits after making the center epiphyseal plate defects of distal femur and to evaluate the effectiveness of bone bridge resection.Methods The histocompatibility of β3-TCP and its impact on the growth of bone bridge were observed in 10 Japanese white rabbits.The other 30 Japanese white rabbits were divided into three groups ( n =10 for each):Group A ( β-TCP marker,bone bridge resection and fat filling),Group B ( β-TCP marker and bone bridge resection) and Group C (simple defect).The effect of bone bridge resection by the marker of β-TCP and the guidance of guide pin was evaluated.Results β-TCP had good biocompatibility after implantation and did not affect the degree of femoral deformity (P ＞ 0.05).The average length of marked side' s femur was ( 85.29 ± 4.73 ) mm and the average valgus angle was ( 12.35 ± 2.53 ) °.The unmarked sides were (84.34 ±2.76) mm and ( 12.52 ±3.26)° respectively.By the marker of β-TCP and the guidance of guide pin,the bone bridge was removed completely.It reduced the degree of femoral deformity thatthe defects after bone bridge resection were filled with fat-fascia flap (P ＜ 0.01 ).The femur shortening lengths of group A,B and C were (4.20 ± 1.36),( 10.26 ± 3.31 ),(6.52 ± 1.62) mm respectively,and the differences of valgus angles were ( 12.00 ± 2.11 ) °,(23.47 ± 4.06) °,( 18.38 ± 10.65 ) °.Conclusion The classic animal model of bone bridge resection in rabbits after making the center epiphyseal plate defects of distal femur can be established by the marker of β-TCP and the guidance of guide pin.