摘要目的 探讨钙结合蛋白S100A4和信号传导及转录活化因子3(STAT3)在甲状腺癌及腺瘤组织中的表达及其与甲状腺癌临床生物学行为的关系.方法 应用免疫组织化学法检测S100A4和STAT3在12例正常甲状腺、23例甲状腺瘤和88例甲状腺癌组织中的表达水平.结果 S100A4在正常甲状腺、甲状腺瘤和甲状腺癌组织中的表达率分别为16.67％(2/12)、58.44％(12/23)和80.68％(71/88),两两比较差异有统计学意义(P＜0.05),S100A4表达水平与甲状腺癌美国肿瘤联合委员会(AJCC)分期、颈部淋巴结转移、包膜浸润明显相关(P ＜0.05);STAT3在正常甲状腺、甲状腺瘤和甲状腺癌组织中的表达率分别为25.00％(3/12)、65.22％(15/23)和85.23％(75/88),两两比较差异有统计学意义(P＜0.05),STAT3表达水平与甲状腺癌AJCC分期、组织分化、颈部淋巴结转移明显相关(P＜0.05).结论 检测S100A4和STAT3有助于评估甲状腺癌的生物学行为和判断甲状腺癌预后.

abstractsObjective To analyze the relationship between the expression of S100A4 and signal transducer and activator of transcription 3 (STAT3) and clinical biobehaviors in thyroid carcinoma and thyroid benign tumor.Methods Immunohistochemistry was used to assess the expression of S100A4 and STAT3 in 12 cases of thyroid normal tissues,23 cases of thyroid benign tumor tissues and 88 cases of thyroid carcinoma tissues.Results The expression rate of S100A4 in normal thyroid tissues,thyroid benign tumor tissues and thyroid carcinoma tissues was 16.67％ (2/12),58.44％ (12/23) and 80.68％ (71/88) respectively with the difference being significant (P ＜0.05).The expression of S100A4 was related thyroid carcinoma to American Joint Committee on Cancer (AJCC) clinical stage,lymph node metastasis and the degree of infiltration (P ＜ 0.05).The expression rate of STAT3 in normal thyroid tissues,thyroid benign tumor tissues and thyroid carcinoma tissues was 25.00％ (3/12),65.22％ (15/23) and 85.23％ (75/88) respectively with the difference being significant (P ＜ 0.05).The expression of STAT3 was related thyroid carcinoma to AJCC clinical stage,differentiation degree and lymph node metastasis (P ＜ 0.05).Conclusion Detecting the expression levels of S100A4 and STAT3 in thyroid carcinoma has certain reference value for judging biological behaviors and evaluating prognosis of patients with thyroid carcinoma.