摘要目的 探讨骨肉瘤组织和骨软骨瘤组织中富含脯氨酸蛋白11(PRR11)和X连锁凋亡抑制蛋白(XIAP)表达及其临床意义.方法 收集2003年3月至2019年6月广东医科大学附属医院资料完整的18例骨软骨瘤和61例骨肉瘤组织标本,使用免疫组织化学法检测PRR11和XIAP的表达水平,并进行相关分析.结果 PRR11在骨肉瘤组织中阳性表达率明显高于骨软骨瘤组织阳性表达率(72.13％比11.11％,x2 =21.277,P＜0.01),PRR11表达水平与骨肉瘤Eneeking分期、肺转移和软组织浸润明显相关(x2 =6.324、6.752、6.416,P＜0.05);XIAP在骨肉瘤组织中阳性表达率明显高于骨软骨瘤组织阳性表达率(65.57％比5.56％,x2=20.055,P＜0.01),XIAP表达水平与骨肉瘤Eneeking分期、肺转移明显相关(x2=6.149、7.478,P＜0.05).结论 PRR11和XIAP在骨肉瘤组织中呈高表达,检测PRR11和XIAP有助于判断骨肉瘤患者病情.

abstractsObjective To analyze the clinical significance of proline-rich protein 11 (PRR11),X-linked inhibitor of apoptosis protein (XIAP) in osteosarcoma tissue and osteochondroma tissue.Methods 18 cases of osteochondroma tissues and 61 cases of osteosarcoma tissues of patients pathologically confirmed From march 2003 to june 2019 on Affiliated hospital of guangdong medical university were collected,The expression of PRR11 and XIAP proteins in osteochondroma tissues and osteosarcoma tissues were detected by using immunohistochemical method.Results The expression rate of PRR11 in Osteosarcoma tissues was higher than that of Osteochondroma tissues (72.13％ vs.11.11％,x2 =21.277,P ＜0.01),the expressions of PRR11 were related to Eneeking stage,lung metastasis and soft tissue involvement of Osteosarcoma (x2 =6.324,6.752,6.416,P ＜0.05);the expression rate of XIAP in Osteosarcoma tissues was high-er than that of Osteochondroma tissues (65.57％ vs.5.56％,x2 =20.055,P ＜ 0.01),the expressions of XIAP were related to Eneeking stage and lung metastasis of Osteosarcoma (x2 =6.149,7.478,P ＜ 0.05).Conclusion PRR11 and XIAP were highly expression in Osteosarcoma,These data indicate that PRR11 and XIAP can be used as an important biomarker to estimate the progression of Osteosarcoma.