摘要肝细胞癌是临床上常见的恶性肿瘤之一，其进展迅速，病死率高，总体预后极差，5年生存率不足18%。故临床上常应用分期系统等方法对肝细胞癌患者进行预后评估，但由于肝细胞癌的异质性极高，这些传统的工具无法对其预后进行精准预测。液体活检是近年来研究的热点，主要通过对体液中的小分子成分(包括循环肿瘤细胞、循环游离核酸、外泌体等)进行分析，进而实时反映肿瘤状况及其预后情况。因此，本文旨在探讨液体活检在肝细胞癌预后中的潜在作用。

abstractsHepatocellular carcinoma (HCC) is one of the most common malignant tumors globally. The rapid progression in HCC contributes to the high fatality rates and poor overall prognosis, with the 5-year survival of less than 18%. For this reason, several methods, including HCC staging systems, are often used to evaluate the prognosis of patients with HCC. However, due to the high heterogeneity of HCC, these traditional tools can not accurately predict its prognosis. In recent years liquid biopsy has become a hot topic, Liquid biopsy is a minimally invasive technology for the detection of molecular components (e.g., circulating tumor cells, circulating cell-free nucleic acids, and exosomes) in body fluid, eventually reflecting the tumor status and its prognosis. Herein, the current review aimed to explore the potential role of liquid biopsy in the prognosis of HCC.