摘要昼夜节律存在于人体的中枢和外周器官中，在生理或病理状态下都发挥着关键的调节作用。缺血再灌注(I/R)损伤是缺血的组织血液循环得到恢复后，组织再次受到额外的损伤。各器官缺血再灌注损伤发生率高，严重危害人类健康。研究结果显示昼夜节律振荡对器官缺血再灌注损伤的发生和严重程度有重要影响，相关信号通路可以作为治疗靶标，具有潜在应用价值，但目前未得到全面总结。我们回顾了昼夜节律振荡与各器官缺血再灌注损伤相关研究，总结了相关信号分子通路，为器官缺血再灌注损伤的预防及治疗提供新的思路。

abstractsCircadian rhythmicity (CR) is involved in the regulation of the central and peripheral organs of the human, and plays a key role in human physiological and pathological state. Ischemia-reperfusion (I/R) is characterized by an initial restriction of blood supply to a tissue followed by the subsequent restoration of perfusion which causes an exacerbation of tissue injury. The incidence of ischemia-reperfusion injury in various organs is high, which seriously endangers human health. Studies have found that circadian oscillation has an important impact on the occurrence and severity of organ ischemia-reperfusion injury. The related signaling pathways can be used as therapeutic targets, with potential application value, but there are not comprehensive summaries. We reviewed the studies on circadian oscillation and ischemia-reperfusion injury, summarized the related signaling molecular pathways, and provided new ideas for the prevention and treatment of ischemia-reperfusion injury.