摘要目的:探讨腹腔镜膀胱部分切除术用于治疗膀胱憩室癌的安全性及有效性。方法:分析2019年1月至2023年5月期间福建医科大学附属泉州第一医院收治的12例膀胱憩室癌患者的临床资料，其中男8例、女4例，年龄45~88岁，平均74岁。这些患者均接受了腹腔镜膀胱部分切除术治疗。评价患者的手术情况、病理结果、术后并发症、术后辅助治疗及随访结果。结果:12例患者均顺利完成腹腔镜膀胱部分切除术，术中未出现明显并发症，术后病理结果均确诊为尿路上皮癌。手术时间为(75±25) min，术中出血量为(10±6) ml，术后住院时间为(4±2) d，患者术后1~3 d恢复肛门排气并进食。术后病理结果均确诊为尿路上皮癌，其中低级别乳头状尿路上皮癌7例(58.3%)、高级别乳头状尿路上皮癌5例(41.7%，含1例合并鳞状细胞分化)；肿瘤分期为pTa期3例(25.0%)、pT1期7例(58.3%)、pT3期2例(16.7%)，免疫组织化学示Ki-67指数39%~85%，1例(8.3%)闭孔淋巴结病理阳性。所有患者术后均接受了膀胱灌注治疗，5例(41.7%)行全身静脉化疗，1例(8.3%)行动脉化疗以进一步预防肿瘤复发。随访16至79个月，11例(91.7%)患者无肿瘤复发，1例(8.3%)患者术后15个月出现肿瘤复发。结论:腹腔镜膀胱部分切除术治疗膀胱憩室癌安全、有效，具有较少的术后并发症和较好的肿瘤控制效果。

abstractsObjective:To explore the safety and efficacy of laparoscopic partial cystectomy in the treatment of bladder diverticular carcinoma.Methods:The clinical data of 12 patients with bladder diverticular carcinoma admitted to Quanzhou First Hospital Affiliated to Fujian Medical University from January 2019 to May 2023 were analyzed, including 8 males and 4 females, aged 45-88 years with an average of 74 years. All patients underwent laparoscopic partial cystectomy. The study evaluated surgical details, pathological results, postoperative complications, adjuvant treatments, and follow-up outcomes.Results:All 12 patients successfully completed laparoscopic partial cystectomy without obvious intraoperative complications. The operation time was (75±25) min, intraoperative blood loss was (10±6) ml, and postoperative hospital stay was (4±2) d. The patients resumed anal exhaust and oral intake 1-3 days after surgery. Postoperative pathological results confirmed that all patients were diagnosed with urothelial carcinoma, including 7 cases (58.3%) of low-grade papillary urothelial carcinoma, 5 cases (41.7%) of high-grade papillary urothelial carcinoma (including 1 case with squamous cell differentiation); tumor staging was pTa stage in 3 cases (25.0%), pT1 stage in 7 cases (58.3%), pT3 stage in 2 cases (16.7%). Immunohistochemistry showed Ki-67 index of 39%-85%, and 1 case (8.3%) had pathologically positive obturator lymph nodes. All patients received postoperative intravesical instillation therapy (gemcitabine or epirubicin, course of 10-12 months), among which 5 cases (41.7%) received systemic intravenous chemotherapy, and 1 case (8.3%) received arterial chemotherapy to further prevent tumor recurrence. During a follow-up period of 16 to 79 months, 11 cases (91.7%) had no tumor recurrence, while 1 case (8.3%) had tumor recurrence 15 months after surgery, who achieved long-term survival after TURBt combined with radiotherapy.Conclusion:Laparoscopic partial cystectomy is safe and effective in the treatment of bladder diverticular carcinoma, achieve good tumor control effect, and ensure the postoperative quality of life of patients, so it is worthy of clinical promotion.