摘要对尿毒症患者血小板膜糖蛋白（GP）Ib含量用两种不同方法进行测定，同时测定血浆中von Wille-brand Factor（vWF）浓度。结果显示尿毒症组血小板膜GPIb含量显著低于对照组（ P<0.01），血透后减少更明显（ P<0.05），两种方法测定的血小板膜GPIb减少之间呈正相关（ r=0.52 P<0.01），尿素氮升高与血小板膜GPIb减少无明显相关关系（ r=-0.2 P>0.05），血浆中vWF也显著高于对照组（ P<0.01），提示：尿毒症患者血小板功能缺陷与血小板膜GPIb缺乏关系密切，尿毒氮升高可能不是直接使GPIb减少的原因，血小板止血功能障碍使vWF代偿性增高，血液中存在抑制vWF与血小板结合的物质。

abstractsWe studied the platelet GPIb with two methods, vWF were determined in uremic patients. Our results showed the platelet GPIb were decreased in uremia ( P<0.01). Post-dialysis GPIb levels were lower than pre-dialysis. There was significant positive correlation between the platelet GPIb levels used two methods ( r=0.52, P<0.01). There was negative correlative between the increment of urea nitrogen and reduction of platelet GPIb. The platelet dysfunction was closely related to decrement of platelet GPIb in uremic patients. Platelet hemostatic dysfuntion raise plasma levels of vWF compensatively. There were toxic metabolic products inhibited vWF binding to platelet in blood.