摘要目的:了解血透患者甲状旁腺素［PTH（1~84）］和血小板胞内游离钙浓度｛pt［Ca 2+］i｝在血压调节中的作用。 方法:用Fura-2荧光测定法和免疫放射法对24例血透患者测定上述两项内容。结果:HD患者的静息pt［Ca 2+］i和PTH（1~84）是升高的，高血压者升高更为明显。静息pt［Ca 2+］i与PTH（1~84）相关。多因素逐步回归显示PTH（1~84）、pt［Ca 2+］i为影响HD患者平均动脉压的主要因素。 结论:PTH（1~84）、pt［Ca 2+］i可能是主要影响尿毒症患者血压的因素。

abstractsObjective:To observe the role of parathyroid hormone PTH (1~84) and platelet cytosolic free calcium {pt [Ca 2+] i} in regulation of blood pressure on hemodialysis (HD) patients. Methods:Fura-2 fluorometry and immunoradioassy werw used to detect PTH (1~84) and pt [Ca 2+] i in 24 HD patients. Results:The resting pt [Ca 2+] i and PTH (1~84) increased in HD cases, and they were significantly higher in uremic patients with hypertension than ones without hypertension. The resting pt [Ca 2+] i was correlated to PTH (1~84) in HD cases. The multivariate stepwise regression analysis showed the PTH (1~84) and pt [Ca 2+] i are probably mains factors to affect the blood pressure in HD cases. Conclusion:PTH (1~84) and pt [Ca 2+] i are main factors affecting the blood pressure in uremic patients.