摘要目的 探讨中国成人血清γ-谷氨酰转移酶(GGT)水平与空腹血糖受损(IFG)的关系,评估年龄、体质指数(BMI)、血压和脂类对该关系的影响.方法 以来自江苏徐州地区的7309名健康体检人群为研究对象,检测受试者GGT、血清谷内转氨酶(GPT)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)以及血糖等相关生化指标.IFG定义为6.1 mmol/L≤空腹血糖(FBG) ＜7.0 mmol/L.血清GGT与空腹血糖受损的相关性采用Pearson相关分析,多变量间的分析采用非条件logistic回归.结果 血清GGT与IFG组中空腹血糖呈正相关(r=0.51,P＜0.01),而与正常血糖组中空腹血糖的相关性较弱(r=0.21,P＞0.05).校正年龄和性别后,GGT与IFG组中空腹血糖存在较强相关性(r=0.53,P＜0.05).进一步校正白细胞、生化指标、血压、BMI后,这种相关性依然存在(r=0.48,P＜0.05).对年龄、性别、BMI、TG、TC、HDL-C、LDL-C、血压进行多因素校正后,通过升高分组变量GGT水平,得出IFG风险比值比(OR)及95％的可信区间(CI)分别为[1.00；0.91 (0.49～ 1.72)；1.27(0.68～ 2.38)；2.31(1.29 ～4.15)；2.42(1.32 ～4.42)；P＜0.05].年龄与GGT交互作用对IFG风险产生影响(P＜0.05).BMI水平对GGT与IFG风险的相关性产生影响.结论 数据结果显示GGT水平与IFG风险相关,BMI水平对GGT与IFG风险的相关性产生影响.

abstractsObjective To investigate the correlation of serum gamma glutamyl transpeptidase (GGT)level with impaired fasting glucose (IFG)and evaluate the modification effects of age,Body Mass Index(BMI),hypertension and lipids in Chinese adults. Methods The study samples were from a community-based health examination survey in Xuzhou,Jiangsu province of China.A total of 7309 subjects with biomarkcrs available were included in the present study.Serum ALT,GGT,triglyceride (TG),total cholesterol (TC),low-density lipoprotein cholesterol ( LDL-C ),high density lipoprotein cholesterol ( HDL-C) and glucose were measured.IFG was defined from 6.1 mmol/L to 7.0 mmol/L (fasting blood-glucose,FBG).Rcsuhs are expressed as mean ± S.E.The correlation between hepatic markers and other variables were assessed using pearson correlation.Logistic regression model (binary regression) was used to calculate the odds ratio (OR) of IFG with 95％ confidence interval (95％ CI).Results After adjusted for age,sex,BMI,blood pressure,TG,TC,LDL-C and HDL-C,the odds ratios ( ORs,95％ CI) of IFG across increasing quintiles of GGT were 1.00,0.91 ( 0.49 - 1.72 ),1.27 ( 0.68 - 2.38 ),2.31 ( 1.29 - 4.15 ) and 2.42(1.32 -4.42) (P for trend ＜0.05).We found significant interactions between GGT and age on IFG risk ( P ＜ 0.05 ).When the joint effects were examined,we found an additive effect of BMI level and GGT levels on fasting blood glucose (FBG).Conclusions The present data indicate serum GGT is related to the risk of IFG in Chinese adults,and BMI level modified in coordination with the relationship.