摘要目的 采用听觉事件相关电位(auditory event-related potential,aERP)对新生儿的认知发展特征进行研究. 方法 采用抛硬币法随机选择江苏省常州市儿童医院新生儿科2013年12月至2014年9月收治的、能充分合作的足月新生儿30例,按日龄分为1～10 d组、11～20 d和21～28 d组,各10例.所有研究对象均排除围产期脑损伤,新生儿神经行为评分＞37分,听力筛查双耳均通过.采用听觉Oddball范式,记录aERP,对新生儿N2波潜伏期及面积与日龄进行相关分析.采用Pearson相关分析对数据进行统计学分析. 结果 (1)3组新生儿N2波潜伏期与日龄呈负相关(r=-0.609,P＜0.05),N2波面积与日龄呈正相关(r=0.689,P＜ 0.01).(2)在Fz、Cz导联,3组新生儿aERP总平均波形图的波形宽大平缓,且曲线不甚平滑,多呈锯齿状;N2波在1～10 d组呈现为多个波峰的低平复合波,在11～20 d和21～28 d组可见N2波逐渐呈现波形规整、高耸的趋势,并渐趋为单波;N2波潜伏期呈逐渐缩短趋势. 结论 随着日龄逐渐增大,新生儿注意、辨别等认知能力渐增强.

abstractsObjective To study the characteristics of cognitive development of newborns with auditory event related potentials (aERP).Methods Thirty full-term neonates who were admitted to Changzhou Children's Hospital and met the inclusion criteria, those with neonatal neural behavioral score over 37 and both ears passed the hearing screening, and exclusion criteria, those who suffered from perinatal brain injury, were sclccted randomly.Thcy wcre divided into three groups according to the days of age (group 1 : 1-10 days;group 2:11-20 days;group 3:21-28 days).aERP was recorded with auditory Oddball paradigm.The data were collected and analyzed by Brain Electrical Source Analysis software.Relationship between N2latencies/areas among the three groups and their age was researched with Pearson correlation analysis.Results During the neonatal period, there was a significant negative correlation between N2 latency and neonatal age in days (r=-0.609, P ＜ 0.05), while significant positive correlation was shown between N2 area and the age (r=0.689, P ＜ 0.05).In Fz and Cz leads, the total average waveform diagram of the three groups showed spacious flat, less smoothed curve, and mostly jagged pattern.N2 area in group 1 showed a complex plurality of peaks, and regular, soaring waves, which changed into single wave thereafter, in group 2 and 3.The N2 latencies tended to shorten gradually.Conclusions Neonatal cognitive competence, including concentration and discrimination ability, would be improved with their growth.