摘要广泛应用的溴代阻燃剂多溴联苯醚（polybrominated diphenyl ethers, PBDEs）污染已成为全球性问题，PBDEs可通过饮食、呼吸和皮肤吸收等方式进入生物体内，并可以通过胎盘和乳汁传递给胎儿和新生儿。评估妊娠期PBDEs母源性暴露水平及其对胎儿发育的影响成为母胎医学及环境科学集中关注的重点问题。本文将针对PBDEs母源性暴露对子代体格生长、神经行为发育、生殖泌尿系统、脏器及免疫功能的影响及相关机制进行综述。

abstractsPollution caused by widely used polybrominated diphenyl ethers (PBDEs) has become a global problem. PBDEs could enter the body through dietary intake, breathing and skin absorption, and can be transmitted to fetus and newborn through placenta and breastmilk. The assessment of maternal exposure level of PBDEs during pregnancy and its impact on fetal development have gained increasing attention in maternal and fetal medicine and environmental science. This article reviews the effects of maternal exposure to PBDEs on the development of offspring and its mechanisms.