摘要目的 总结分析下肢动脉旁路移植术后移植物闭塞的治疗经验.方法 回顾性分析2002年7月至2009年9月64例单侧下肢动脉旁路移植术后移植物闭塞患者的临床资料.共发生115例次移植物闭塞,其中8例次末次闭塞时行保守治疗,其余107例次行手术治疗,包括单纯人工血管取栓术32例次,再次人工血管旁路移植术27例次,人工血管取栓并球囊成形术17例次,截肢术13例次,人工血管取栓术并腘动脉内膜剥脱术10例次,人工血管闭塞并感染取出后保守治疗4例次,自体大隐静脉远侧旁路移植术3例次,自体干细胞移植1例次.结果 1例患者因术后急性肾功能衰竭死亡,3例随访中死亡.3例末次手术后失访,2例保守治疗失访;55例患者随访4～70个月,平均39个月.其中35例患者移植物通畅(通畅率为63.6%).12例患者移植物闭塞后截肢(21.8%),总保肢率为78.2%.结论 对于下肢动脉旁路移植术后移植物闭塞的患者,再次旁路移植术以及人工血管切开取栓+内膜剥脱术或球囊成形术的近期效果较好.

abstractsObjective To explore the experience of management of graft occlusion in patients with lower extremity bypass grafting. Methods From July 2002 to September 2009, 115 cases of graft occlusion were treated in 64 patients with lower extremity arterial bypass, including medical therapy for 8 cases and redo operations for 107 cases: graft thrombectomy alone for 32 cases, redo bypass operation with prosthetic grafts for 27 cases, graft thrombectomy plus balloon angioplasty for 17 cases,major amputation for 13 cases,graft thrombectomy plus endarterectomy for 10 cases, removal of occluded graft with infection for 4 case,distally bypass grafting with autologous saphenous vein for 3 case, and autologous stem cell transplanting for 1 case. Results One patient died of acute renal failure during peri-operaitve period and 3 patients died during follow-up period, 5 patients were lost to follow-up including 2 with medical therapy. The remaining 55 patients were followed up for 4 to 70 months (average 39 months): medical therapy for 8 patients, major amputation for 12 patients (21.8%), and patent grafts after reconstruction in 35 patients (63.6%).Conclusion For graft occlusions after lower extremity bypass grafting, redo bypass operation and graft thrombectomy plus endarterectomy or balloon angioplasty may produce better early results.