摘要目的 验证基于西方人样本资料的Partin表预测我国前列腺癌患者术后病理特征的准确性.方法 回顾性分析2006年1月到2010年2月所有接受前列腺癌根治术患者的资料,筛选出术前未接受内分泌治疗且影像学检查未见盆腔淋巴结增大及远处转移的病例,收集前列腺特异性抗原检测值、Gleason评分、临床分期及术后病理分期等数据.根据术前临床指标按照Partin表分别预测四种术后病理情况的发生概率,再与实际结果 进行对照,利用受试者工作特征曲线下面积评估Partin表的准确性.结果 与构建Partin表的基础样本人群相比,本研究组人群血清前列腺特异性抗原水平、Gleason评分偏高,临床分期偏晚.器官局限、包膜侵犯、精囊侵犯及淋巴结转移这四种术后病理情况的发生率分别为62.3%、16.7%、12.3%及8.8%.利用Partin表预测上述术后病理特征的4条受试者工作特征曲线下面积分别为0.735、0.653、0.601及0.845.结论 对于我国前列腺癌患者,Partin表预测淋巴结转移的准确性很高,预测器官局限性疾病的准确性尚可接受,而预测包膜侵犯及精囊侵犯的准确性则较差.

abstractsObjective To validate the 2007 Partin tables externally, which are based on the population of United States, using a cohort of Chinese prostate cancer patients. Methods All of the patients enrolled and underwent radical prostatectomy between January 2006 and February 2010 were reviewed. The cases without preoperative hormone therapy and pelvic lymph node involvement according to radiologic tests were used for the external validation of the 2007 Partin tables. A comparative analysis of the clinical and pathological parameters of this Chinese cohort and Partin tables cohort was performed. Values of areas under the receiver operating characteristic (ROC)curve were used to assess predictive accuracy for the Chinese cohort. Results The mean age of the whole cohort was 67 years. The serum prostate specific antigen level,Gleason score and clinical stage of this cohort were higher than the Partin tables cohort. The pathological outcomes analysis revealed that the rates of organ confined disease, capsular penetration, seminal vesicle involvement and lymph node involvement were 62. 3%, 16. 7%, 12. 3% and 8.8%, respectively. The area under the ROC curve (AUC)for organ confined disease, capsular penetration, seminal vesicle involvement and lymph node involvement were 0. 735, 0. 653, 0. 601 and 0. 845. Conclusions The Partin tables discriminate well for Chinese patients at risk for positive lymph node. The discrimination of organ confined disease is also acceptable and the discrimination of capsular penetration and seminal vesicle involvement is more limited.