摘要近年的研究结果表明，微环境在肿瘤进展中发挥重要作用，而肿瘤间质是微环境的主要成分，所以肿瘤间质比（TSR）可间接反映肿瘤与微环境的关系，其在肿瘤临床研究中被逐步重视。而间质丰富是胰腺导管腺癌的重要特征之一，所以明确TSR在胰腺癌临床研究中的价值显得尤为重要。目前TSR的评价方法较多且不同研究间存在差异，但与基于全组织大切片病理学和影像学的整体评价的结论基本一致。此外，TSR与生存预后的关系取决于评价方法，整体评价TSR>1与预后不良密切相关，所以TSR有望优化现有肿瘤分期。术前影像学TSR评价拓宽了其在胰腺癌个体化精准诊疗中的临床应用前景。当然，TSR评价方法优劣的比较及与预后的关系尚待多中心大样本研究明确。

abstractsThe current studies show that tumor microenvironment of malignant tumor plays critical roles in the tumor progression. The stroma is the main component of tumor microenvironment and the tumor-stroma ratio (TSR) may reflect the relationship of tumor and tumor microenvironment, which has drawn increasing attention from the field of clinical research of cancer.With poor survival,pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by an intense fibrotic stromal response and the clinical researches related with TSR in PDAC are more significant for patients management compared with that in other tumors.The evaluation methods for TSR are not inconsistent in different studies. But the evaluation result of TSR in pathological method based on whole-mount slide image agrees with that in radiological method, so as the prognosis prediction, that TSR>1 indicated poor prognosis.So TSR can be a stratification marker for patients with PDAC to optimize the tumor stage system used currently. The radiological evaluation before surgery widen the clinical application of TSR in the precise and individual management of patients with PDAC.The comparison for evaluation methods of TSR and the relationship of TSR and prognosis are still needed thorough investigation in ongoing studies with a larger number of patients in multiple centers.