摘要骨关节炎的发病机制尚不明确，目前的治疗方法仍不能有效阻止疾病进展。生物模型是研究疾病的重要工具，二维、三维细胞培养模型及生物反应器培养模型等体外模型，以及自发性、遗传修饰性、侵入性及非侵入性模型等动物体内模型，可模拟疾病的阶段性变化或发展全过程。对以上模型的研究是探索骨关节炎发生、发展过程的重要手段，亦是开发和评价治疗方法的重要依据。本文对骨关节炎模型及其特点进行综述，以期为骨关节炎的研究提供参考。

abstractsThe mechanism of osteoarthritis is still not completely clear,the current treatment can not effectively prevent the disease from progressing.In order to study osteoarthritis,researchers have developed various models,including in vitro models (two-dimension and three-dimension cell culture models and bioreactor culture models) and in vivo models (spontaneous,genetically modified,invasive and non-invasive models).These models are important tools for studying the mechanism of disease occurrence and development,which can simulate the whole process or a certain stage of pathological changes,as well as evaluating the effect of treatment.This paper reviews the osteoarthritis models and their characteristics in order to provide reference for osteoarthritis research.