摘要目的 研究运动性股骨头缺血坏死幼年动物模型的制作方法.方法 共选取健康幼年雄性新两兰大白兔10只,均经X线检查证实骨骺未闭.对实验兔右侧髋关节进行大范围、高强度被动运动及股骨头向心性撞击,左侧为自身对照侧,未给予特殊处理.经4周干预后对实验兔舣侧髋关节进行X线、MRI检查,随后取双侧股骨头标本进行大体肉眼观及组织学检查,以了解股骨头坏死情况.结果 幼年新西兰大白兔经4周干预后,通过X线检查发现其运动侧股骨头局部密度增高,骨骺高度降低,骨小梁模糊;MRI检查发现运动侧髋关节囊内积液,T1和T2相均可见股骨头内有片状低密度信号区;组织学检查显示运动侧骨小梁稀疏、变细、断裂,骨小梁排列不规则.结论 对幼年新西兰大白兔髋关节进行大范围被动运动及股骨头向心性撞击,可成功复制出股骨头缺血性坏死幼年动物模型.

abstractsObjective To establish an immature rabbit model of avascular necrosis of the femoral head in-duced by exercise. Methods Ten male, immature New Zealand white rabbits were subjected to large range, in- tense passive movement and concentric impingement on their right hips for 4 weeks. The left hips were used as self-controls. Then X-ray and magnetic resonance imaging, gross anatomical observation and histological examination were used to evaluate avascular necrosis of the femoral head. Result After 4 weeks, avascular necrosis of the femoral head was successfully replicated. Increased bone density, decreased osteoepiphysis height and indistinct bone trabec-ula were found in X-rays of the right hips. In MRI images obvious joint hydrops could be detected in all right hips, and schistic low signal areas in the femoral head could be seen in TIWI and T2WI images. Thin bone trabeculae of low density, with irregular and broken structures, were also found in H-E sections. Conclusion An immature rab-bit model of avascular necrosis of femoral head can be successfully induced through large range, intense, passive movement and concentric impingement.