摘要目的 探讨功能性便秘患者的认知功能和情绪状态及其关联性.方法 选取35例功能性便秘患者及24例健康志愿者,在执行听觉Oddball序列任务时,采集事件相关电位(ERP)行为学及脑电数据.ERP检测前进行汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、症状自评量表(SCL-90)及艾森克人格量表(EPQ)评估,并将各评分结果进行统计学分析比较.结果 功能性便秘组患者汉密尔顿抑郁、焦虑总分和SCL-90中躯体化、强迫、抑郁、焦虑、精神病性及EPQ中内外向和神经质因子与健康对照组对比,差异均有统计学意义(P＜0.05).功能性便秘组和健康对照组的ERP-P300反应时分别为(474.28 ±128.29)ms和(424.28±94.95) ms,准确率分别为(97.16±4.17)％和(98.02±2.65)％,组间比较,差异无统计学意义(P＞0.05).功能性便秘组在F3和F7位点上的P300波幅均较健康对照组增高(P＜0.05),但其相应的P300潜伏期比较,差异无统计学意义(P＞0.05).结论 功能性便秘患者有焦虑抑郁情绪,可能存在躯体化、强迫等方式应对焦虑抑郁的痛苦体验；其听觉通道信息加工中涉及内隐加工的认知功能可能存在异常.

abstractsObjective To investigate the relationship between cognitive function and emotional status in functional constipation patients.Methods Thirty-five functional constipation patients (the functional constipation group) and 24 healthy controls (the HCs) were enrolled in an event-related potential (ERP),behavior and electroeneephalogram study while performing an oddball auditory task.Response time,accuracy,latency and P300 amplitude were compared between the two groups.The Hamilton depression rating scale (HAMD-17),Hamilton anxiety scale (HAMA),symptom check list-90 (SCL-90) and Eysenck personality questionnaire (EPQ) were administered prior to the oddball task.Results The average HAMD-17,HAM A and SCL-90 (the somatization,obsessive-compulsive disorder,depression,anxiety and psychosis dimensions) scores of the functional constipation group differed significantly from those of the HCs.The intro-extraversion and neurosis dimensions of the EPQ were also significantly different.There was no significant difference in response time or latency between the two groups.The ERP results showed that the P300 amplitudes at the F3 and F7 sites were significantly different between the functional constipation group and the HCs.But there was no significant difference in P300 latencies at F3 or F7 between the two groups.Conclusions The findings suggest that patients with functional constipation are more susceptible to depression and anxiety,as well as somatization,obsessive-compulsive tendencies and other neurotic personality characteristics.Patients may employ psychological defense mechanisms to avoid the depression and anxiety.The ERP results imply there may be the implicit cognitive dysfunction with emotion in patients with functional constipation.