摘要目的 通过对中国HIV-1感染缓慢进展者(TP)和典型进展者(TP)杀伤细胞免疫球蛋白样受体(KIR)基因频率的研究,探讨中国人群K/R基因多态性与HIV-1感染者疾病进程的关系.方法 采用聚合酶链反应-序列特异性引物(PCR-SSP)技术,分析43例HIV-1感染SP和38例TPKIR基因位点的多态性.结果 SP组和TP组的KIR2DS3等位基因频率分别为3.6%和14.2%,SP组显著低于TP组,两组的KIR2DS3等位基因频率差异具有统计学意义(P=0.018,OR=0.210,95%CI=0.053-0.833);SP组的活化性KIR基因数目低于TP组,但差异无统计学意义(P=0.208).结论 低表达KIR2D53基因可能是延缓中国HlV-1感染者疾病进程的保护因素之一.

abstractsObjective To investigate the killer cell lg-like receptors (KIR) gene frequency of HIV-1 infected slow progressors(SP) and typical progressors(TP), and to analyze the interaction between KIR alleles and the progression of HIV-1 infection in Chinese population. Methods Eighty-one HIV-1 posi-tive individuals including 43 SPs and 38 TPs were recruited. Carriage of KIR genes was assessed using poly-merase chain reaction sequence-specific primers (PCR-SSP) assays. Results KIR2DS3 gene frequency was significantly lower in SP group (3.6%) than that in TP group (14.2%), P =0. 018 ,OR =0. 210,95% CI =0.053-0.833. The number of activating KIR genes was less in SP group than that in TP group, but was not significant (P = 0. 208). Conclusion Lower KIR2DS3 gene frequency may potentially be associated with slower progression to AIDS in Chinese population.