摘要目的 了解上海市金山区健康人群麻疹抗体水平,为制定和改进本区麻疹免疫防控策略提供依据.方法 分层抽样,男女各半,本市与流动人口各半,采集健康人群12个年龄组的390份血清,采用间接酶联免疫吸附法(ELISA)定量检测麻疹IgG抗体浓度,按抗体阳性水平进行分组,对不同人群麻疹抗体水平比较分析.结果 全人群麻疹抗体阳性率为78.21%,保护性水平达41.28%.男女之间及本市人口与流动人口之间抗体阳性率差异均无统计学意义(P均>0.05).各年龄组抗体水平之间差异有统计学意义(χ2=191.214,P<0.01);≥1岁人群抗体阳性率超过80.00%,其中,3~6岁儿童抗体阳性率达100.00%,≥40岁人群抗体阳性率超过90.00%;<8月龄儿童为易感人群,抗体水平阳性率(10.00%)最低;保护率,8月龄~9岁儿童最高,其次是≥40岁人群, 10~39岁人群麻疹抗体水平主要在200~800 mIU/ml.≥8月龄人群免疫史状况不同,抗体水平差异无统计学意义(χ2=1.140,P>0.05).结论 2015年金山区人群麻疹抗体平均水平较高,已建立较好的免疫屏障,阳性率有待进一步提高,<8月龄儿童及10~39岁人群是主要易感人群.建议重点做好易感人群和育龄妇女含麻疹成分疫苗的接种,提高人群免疫屏障.

abstractsObjective To detect the levels of anti-measles antibody in a healthy population in Jin-shan District of Shanghai and to provide references for making a better immunization strategy against measles in this area. Methods Stratified sampling was used to collect 390 serum sample in 12 age groups with an equal number of males and females as well as resident and floating population. Indirect enzyme-linked immu-nosorbent assay (ELISA) was performed to detect the concentrations of IgG antibody against measles in dif-ferent groups. Results The overall positive rate and protective rate of anti-measles antibody were 78.21% and 41.28%, respectively. No significant difference in the positive rates of antibody was found between males and females, or resident and floating population (P>0.05). Antibody levels varied significantly among different age groups(χ2=191.214,P<0.01). More than 80.00% of the people aged≥1 year were positive for anti-measles antibody and the positive rates in children 3 to 6 years old and people aged ≥40 years reached 100% and over 90.00%,respectively. Infants under 8 months of age,having the lowest posi-tive rate of antibody(10.00%),were susceptible to measles. The highest protective rate was found in chil-dren aged 8 months to 9 years,followed by that in people≥40 years. Levels of anti-measles antibody in peo-ple aged 10 to 39 years mainly ranged from 200 mIU/ml to 800 mIU/ml. No significant difference in anti-body levels was found among people aged≥8 months who had different immunization histories(χ2=1.140,P>0.05). Conclusion The average level of anti-measles antibody was high in Jinshan District in 2015,in-dicating that the people in that area had a relatively high immunity to measles,but the positive rate of anti-body needed to be further improved. Infants under 8 months old and people 10 to 39 years old were the main susceptible groups. It is suggested that measles vaccination efforts should be focused on susceptible popula-tion and women of childbearing age to improve herd immunity.