乙型肝炎病毒共价闭合环状DNA(cccDNA)检测和清除的研究进展

Advances in the detection and clearance of hepatitis B virus covalently closed circular DNA ( cccDNA)

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摘要慢性乙型肝炎是世界性的一个公共卫生问题,现在治疗药物不能完全清除肝细胞核中的乙型肝炎病毒共价闭合环状DNA(covalently closed circular DNA,cccDNA),它的存在导致了病毒的持续感染,所以很难彻底治愈.目前对cccDNA的研究越来越受到重视,只有对其进行全面的了解,才能更好地寻找治愈乙型肝炎病毒感染的方法.现对乙型肝炎病毒cccDNA的结构和调节机制,以及检测和清除的研究进展进行综述.

abstractsChronic hepatitis B ( CHB) is a worldwide public health problem and current therapeu-tic drugs cannot completely eliminate the covalently closed circular DNA ( cccDNA ) of hepatitis B virus ( HBV) in the liver cell nucleus. The presence of cccDNA leads to the persistent HBV infection, which is hard to be completely eliminated. At present, the research on cccDNA is getting increasing attention. Only by comprehensively understanding it can we find a better way to cure HBV infection. This article reviewed the structure, regulation, detection and elimination of HBV cccDNA.

作者田原 ^[1] 任锋 ^[1] 学术成果认领

作者单位首都医科大学附属北京佑安医院,北京市肝病研究所,100069 ^[1]

关键词乙型肝炎病毒 cccDNA 检测清除 HBV cccDNA Detection Elimination

主题词乙型肝炎病毒(Hepatitis B virus)矮壮素(Chlormequat)研究(Research)感染(Infection)乙型肝炎, 慢性(Hepatitis B, Chronic)

栏目名称综述

DOI 10.3760/cma.j.issn.0254-5101.2019.11.011

发布时间 2019-12-05

基金项目

国家自然科学基金项目 北京市自然科学基金项目 首都特色临床应用研究 北京市卫生系统高层次卫生技术人才培养计划 天晴肝病基金项目 科技部传染病重大专项项目 首都临床诊疗技术研究及示范应用 2018 年度首都医科大学附属北京佑安医院中青年人才孵育项目(YNKTQN20180202) National Natural Science Foundation of China Beijing Municipal Natu-ral Science Foundation Applied Research for the Clinical Characteristics of Capital High-level Technical Personnel Training Plan of the Beijing Health System Tianqing Liver Disease Foundation of CFHPC National Science and Technology Key Project on"Major Infectious Diseases" Bei-jing Municipal Science & Technology Commission Scientific Research Project of You-an Hospital, CCMU, 2018