摘要白细胞介素-22(interleukin-22, IL-22)是IL-10家族中的一种炎症细胞因子，能作用于多种组织器官的上皮细胞和成纤维细胞。作为炎症细胞因子，IL-22在一些炎症组织持续增强炎症作用，具有潜在致病效应；但与其他炎症细胞因子不同，IL-22可以促进细胞增殖、组织器官再生。因此，在多种组织器官中，IL-22的修复作用广受关注。现对IL-22的结构与细胞来源、受体与信号传导及其在组织器官修复过程中的作用作一综述。

abstractsInterleukin-22 (IL-22), an inflammatory cytokine in IL-10 family, can play a role in epithelia and fibroblasts in various tissues and organs. As an inflammatory cytokine, IL-22 has potential pathogenic effect by enhancing inflammation in some inflammatory tissues. However, IL-22 can also promote cell proliferation and tissue regeneration. This review provides an overview of the structure and source of IL-22, its receptor and signaling transduction, and its function in repair and regeneration of tissues and organs.