摘要核孔蛋白50 (nucleoporin 50，Nup50)参与构成核孔复合体的核篮结构，主要包括N结构域(连接importin α)、F结构域(连接importin β)和R结构域(连接Ran)，其中N结构域包括两个importin α结合片段。目前关于Nup50在入核转运中的作用机制存在两种解释："三相开关"模型和解聚回收模型。Nup50不仅参与物质运输，还可调控基因组结构和基因表达。此外，Nup50参与病毒感染与复制过程，临床研究表明，Nup50与乙型肝炎病毒和人类免疫缺陷病毒1的感染有关。目前关于Nup50与病毒感染的关系尚无深入研究，本综述旨在通过总结Nup50生物学特性及其与病毒感染关系的研究进展，为今后研究Nup50与病毒感染的关系提供线索和思路。

abstractsNucleoporin 50 (Nup50) is a component of nuclear basket in nuclear pore complex. It includes three main domains: N domain binding to importin α, F domain binding to importin β and R domain binding to Ran. The N domain has two importin α-binding segments. There are mainly two models for explaining the role of Nup50 in nuclear import: tri-stable switch and disassemble-recycle model. Nup50 not only participates in nuclear import, but also regulates genome organization and gene expression. In addition, Nup50 is involved in the process of viral infection and replication. There is some evidence that Nup50 is related to hepatitis B virus and human immunodeficiency virus 1 infections. However, there are few researches on the relationship between Nup50 and viral infection. This article summarized the progress in the function of Nup50 and its relationship with viral infection, aiming to provide new ideas for the following in-depth study.