摘要Lung major resections involving bronchovascular reconstruction pose a surgical challenge due to their technical complexity and frequency. The traditional techniques to perform vascular or bronchial reconstructions through multiportal video-assisted thoracoscopic surgery (VATS) approach can be applied also by uniportal VATS approach. Nevertheless, specific tools have already been developed in order to facilitate these procedures through uniportal VATS approach increasing comfort and workspace through the single port utility. These procedures must be performed just in very highly uniportal VATS trained teams and it is recommended that teams who perform these techniques previously have completed the advanced learning curve for lung major resections through uniportal VATS approach. The aim of this paper is to describe the major key points for performing most frequent bronchovascular reconstructions through uniportal VATS approach in a safe and feasible way. Operative technique is step by step described in order to safely perform most common uniportal VATS left/right side lung major bronchovascular resections and reconstructions. Specific tip and tricks are detailed in order to facilitate vascular control, bronchovascular reconstructions and unexpected bleeding control through uniportal VATS approach.