摘要目的 通过在健康家养猪进行超声内镜引导下腹腔神经节穿刺操作训练探讨其可行性和应用价值.方法 选择6只健康家养猪用于研究.术前肌内注射盐酸氯胺酮10 mg/kg镇静,动物安静后给予静脉缓慢注射3%戊巴比妥钠0.8 ml/kg.麻醉稳定后进行穿刺操作并植入空粒子,术后行CT增强扫描以辅助判断穿刺是否成功.结果 试验动物均无死亡,除1只家猪穿刺后CT扫描发现粒子在胃腔内,隔日再行穿刺种植粒子成功,其余均一次性穿刺成功.行CT增强扫描发现粒子定位准确,均匀分布于腹主动脉腹腔干起始部的两侧.结论 家猪的解剖结构与人类相似,可作为初学者进行超声内镜引导下腹腔神经丛穿刺术培训的理想动物模型.

abstractsObjective To explore the feasibility of establishing porcine model for training of endoscopic ultrasound (EUS) guided celiac plexus paracentesis.Methods A total of 6 healthy pigs were sedated with an intramuscular injection of Ketamin at 10 mg/kg,followed by intravenous injection of 3% pentobarbital at 0.8 ml/kg.EUS was then performed and empty seeds were implanted into celiac plexus.Enhanced CT scan was performed to confirm the location of the implanted seeds.Results No animal died after the procedure.All seeds were accurately distributed on both sides of the celiac trunk except in one pig the seed was found in stomach by CT scan and was re-implanted another day.Conclusion Pigs are similar to human in anatomic structure and they can be excellent models for beginner endoscopy physicians to acquire the skill of EUS guided celiac plexus paracentesis.