摘要目的 探讨经口内镜肌切开术(POEM)对贲门失弛缓症患者食管动力的影响.方法 对3例贲门失弛缓症患者POEM治疗前后的食管测压结果进行对比分析.结果 术后3例患者食管下括约肌压力(LESP)和食管上括约肌残余压(UESRP)均低于术前,且差异有统计学意义(P＜0.05)；术后食管下括约肌残余压(LESRP)有2例明显降低至正常值,有1例变化不大,仍高于正常,平均值较术前降低但差异无统计学意义；术前3例患者均有食管蠕动波消失,术后食管蠕动波均无改善；3例患者术前食管下括约肌松弛率( LESRR)均低于正常值,术后仍均低于正常；食管上括约肌压(UESP)平均值术后较术前降低,但差异无统计学意义.结论 POEM近期能明显改善贲门失弛缓症患者的食管动力学特征.

abstractsObjective To determine the effect of peroral endoscopic myotomy (POEM) on esophageal manometry in patients with achalasia.Methods Esophageal manometric data of 3 patients with achalasin before and after POEM was retrospectively analyzed.Results The post-POEM lower esophageal sphincter pressure (LESP) and upper esophageal sphincter residual pressure (UESRP) were significantly lower than those of before ( P ＜ 0.05 ).The average post-POEM lower esophageal sphincter residual pressure (LESRP) decreased (P ＞0.05),with significant decrease to normal level in 2 patients and almost unchanged (above normal) in the other.The esophageal aperistalsis remained after POEM in all 3 patients.The lower esophageal sphincter relaxing rate (LESRR) remained lower than normal after POEM as before.The average upper esophgeal sphincter pressure (UESP) decreased after POEM without statistical significance.Conclusion POEM can improve the outcomes of esophageal manometry in patients with achalasia in the short term.