摘要目的 评价抗反流黏膜切除术治疗胃食管反流病的临床有效性和安全性.方法 2015年12月至2018年7月,郑州大学第一附属医院消化内科行抗反流黏膜切除术的18例胃食管反流病病例资料纳入回顾性研究,统计治疗效果(治疗后烧心及反流症状改善情况、24 h食管pH监测结果等)以及并发症发生情况.结果 18例均成功进行了抗反流黏膜切除术,操作成功率为100％,其中8例行ESD、10例行EMR.24 h食管pH监测结果显示,治疗后Demeester评分、pH<4时间百分比、总反流事件、pH<4时间长于5 min的反流次数较术前均明显降低[(20.16±9.12)分比(74.16±20.03)分、(2.70±0.88)％比(6.42±1.37)％、(43.78±19.68)次比(156.56±41.22)次、(2.89±1.68)次比(9.89±2.95)次,P均<0.05].无术后出血、穿孔、感染病例.随访3～34个月,烧心及反流症状改善总有效率为89％(16/18).胃镜随访显示18例贲门均较前缩紧,收缩良好;16例反流性食管炎较前明显好转,黏膜糜烂愈合.结论 抗反流黏膜切除术治疗胃食管反流病安全有效,且简单易行.

abstractsObjective To assess the efficacy and safety of the endoscopic anti-reflux mucosectomy for gastroesophageal reflux disease. Methods Data of 18 patients with gastroesophageal reflux disease who underwent endoscopic anti-reflux mucosectomy at the First Affiliated Hospital of ZhengZhou University from December 2015 to July 2018 were retrospectively studied. The therapeutic effects ( improvement of heartburn and reflux symptoms, 24 h esophageal pH monitoring) and complications were analyzed. Results Anti-reflux mucosectomy was performed successfully in all patients with successful rate of 100％. ESD was performed in 8 cases and EMR in 10 cases. 24 h esophageal pH monitoring results showed that the Demeester score, the time percentage of pH < 4, total reflux events and reflux times of pH < 4 with time longer than 5 minutes after treatment were significantly lower than those before treatment (20. 16±9. 12 VS 74. 16±20. 03, (2. 70±0. 88)％ VS (6. 42±1. 37)％, 43. 78±19. 68 VS 156. 56±41. 22, 2. 89±1. 68 VS 9. 89±2. 95, all P<0. 05) . No bleeding, perforation or infection was observed after the procedure. During a follow-up period of 3-34 months, symptom relief rate was 89％ (16/18). A tightened cardiac was noted in 18 cases and recovery of mucosal damage was found in 16 patients. Conclusion Anti-reflux mucosectomy is safe, effective and easy to operate for gastroesophageal reflux disease.