摘要目的:探讨抗血小板药物治疗对肠息肉内镜切除术后出血并发症的影响。方法:回顾性分析2015年1月—2017年12月539例行肠镜下息肉切除术患者的临床资料，根据有无使用抗血小板药物分为抗血小板治疗组(n＝88)和非抗血小板治疗组(n＝451)，2组肠息肉内镜治疗术后出血发生率差异行卡方检验。再根据所用抗血小板药物将抗血小板治疗组分成拜阿司匹林组(n＝59)和氯吡格雷组(n＝29)，并与非抗血小板治疗组一起，对肠息肉内镜治疗术后出血发生率差异行3组间卡方检验。结果:肠息肉内镜治疗术后出血总发生率为3.0%(16/539)，抗血小板治疗组与非抗血小板治疗组分别为3.4%(3/88)和2.9%(13/451)，2组肠息肉内镜治疗术后出血发生率差异无统计学意义( P>0.05)。拜阿司匹林组肠息肉内镜治疗术后出血发生率为3.4%(2/59)，氯吡格雷组为3.4%(1/29)，拜阿司匹林组、氯吡格雷组及非抗血小板治疗组3组间肠息肉内镜治疗术后出血发生率差异亦无统计学意义( χ2＝0.561， P＝0.642)。 结论:抗血小板药物治疗对肠息肉内镜治疗术后出血并发症无明显影响。

abstractsObjective:To investigate if antiplatelet agents increase postoperative bleeding risk in patients receiving endoscopic resection of intestinal polyps.Methods:Data of 539 patients who received endoscopic polypectomy from January 2015 to December 2017 in Tianyou Hospital were collected in this retrospective study. Patients were divided into two groups, including antiplatelet therapy group (n=88), which consisted of aspirin-treated subgroup (n=59) and clopidogrel-treated subgroup (n=29), and non-antiplatelet therapy group (n=451). The bleeding incidences after endoscopic polypectomy were compared among groups by Chi-square test.Results:The postoperative bleeding incidence in all 539 patients was 3.0% (16/539). And the incidences in the antiplatelet groups and the non-antiplatelet group were 3.4% (3/88) and 2.9% (13/451), respectively ( P>0.05). Also, there was no statistical difference in the aspirin-treated subgroup (3.4%, 2/59), clopidogrel-treated subgroup (3.4%, 1/29) and non-antiplatelet treated group in the incidence of postoperative bleeding ( χ2=0.561, P=0.642). Conclusion:Antiplatelet agents including aspirin or clopidogrel may not increase the postoperative bleeding risk in patients receiving endoscopic resection of intestinal polyps.