摘要本文研究了肝硬化时胃粘膜屏障功能、胃粘膜血流量及各种胃肠激素水平的变化，以期探讨肝硬化合并溃疡的发病机理。结果表明肝硬化时胃粘膜血流量均明显低下，其减少程度似与局部组织学改变有关，而其血中的胃泌素、生长抑素及胰高糖素的浓度均有明显升高。提示：肝硬化时激素及血流量的改变相互影响，并导致攻击因子增强及粘膜的抗损伤能力降低，从而促使溃疡形成。

abstractsWe have observed the changes of gastric transmucosal potential difference, gastric mucosal blood flow and gut hormones level in 44 patients (20 general peptic ulcer, 12 liver cirrhosis and 12 liver cirrhosis with peptic ulcer) and in 12 rats with liver damage in order to evaluate the pathogenesis of liver cirrhosis with peptic ulcer. The results showed that in the rats with liver damage a significant decrease of gastric mucosal blood flow (GMBF) rate was observed at the antrum and the body as compared with normal controls. The blood levels of gastrin, somatostatin and glucagon markedly increased. There is an interaction between gut hormone and the change of GMBF, which may exert influence on the gastric mucosal barrier function, and thus the patients with liver cirrhosis are susceptible to peptic ulcer.