摘要目的 对750例健康儿童心率变异性(heart rate variability,HRV)进行分析,观察正常值范围及HRV与年龄的关系.方法 对750例来我院体格检查的正常健康儿童分为以下6个年龄组:新生儿组(＜1个月)、婴儿组(1个月～1岁)、幼儿组(1～3岁)、学龄前组(3～6岁)、学龄组(6～11岁)和青春期组(11～16岁),进行24 h动态心电图检测,分析HRV时域(SDNN、SDANN、PNN50、rMSSD)及频域(TF、VLF、LF、HF、LF/HF)结果.结果 (1)各年龄组HRV时域分析SDNN、SDANN、rMSSD差异有统计学意义(P＜0.05或P＜0.01),随年龄增长,HRV有增大趋势.(2)HRV频域分析TF、VLF、LF、HF差异有统计学意义(P＜0.01),数值随年龄增大而增大.结论 不同年龄段HRV时域及频域结果不同,HRV随年龄增加而增大,可对临床研究异常HRV提供参考依据.

abstractsObjective To investigate the range of normal values of heart rate variability (HRV) in 750 healthy children,and to explore the relationship between the value of HRV and age. Methods A total 750 healthy children were randomly divided into six groups according to their ages as follows: group Ⅰ ( less 1 month), group Ⅱ ( 1 month to 1 years old), group Ⅲ ( 1 to 3 years old), group Ⅳ (3 to 6 years old), group Ⅴ (6 to 11 years old)and group Ⅵ( 11 to 16 years old). HRV time domain value(SDNN、SDANN、PNN50、rMSSD)and spectral power value( TF、VLF、LF、 HF、LF/HF)were measured by 24 dynamic electrocardiogram in all children. Results (1)The HRV time domain values( SDNN 、SDANN、rMSSD)were increased with age, there were significant differences among six groups ( P ＜ 0.05 and P ＜ 0. 01 ). ( 2 ) The spectral power values ( TF、VLF、LF、HF) comparison showed significant differences among six groups( P ＜0. 05 and P ＜0. 01 ). Conclusion HRV varies significantly with age, and it increases with age in children. The values generated in this study may be useful in determining abnormal ranges of HRV.