摘要Ventricular arrhythmias(VA)include premature ventricular contractions(PVC),ventricular tachycardia(VT),ventricular flutter or defibrillation(VFL/VF).Although commonly related to structural heart disease,a significant percentage of VA are idiopathic(occurring in patients with otherwise normal hearts).Classic antiarrhythmic drugs(AADs)for VA have limited effectiveness,and pose the risk of life-threatening VT/VF.Very few AADs have been successful in the last few decades,due to safety concerns or limited benefits in comparison to existing therapy.Amiodarone has emerged as the leading antiarrhythmic therapy for termination and prevention of VA in different clinical settings because of its proven efficacy and safety.For VT/VF,implantable cardioverter defibrillator(ICD)appear to be the unique,yet unsatisfactory,solution.Indications for ICD have evolved considerably from initial implantation exclusively in patients who had survived one or more cardiac arrests and failed pharmacological therapy.Multipie clinical trials have established that ICD use results in improved survival compared with antiarrhythmic agents for secondary prevention of sudden cardiac death(SCD).Large prospective,randomized,multicenter studies have also demonstrated that ICD therapy is effective for primary prevention of sudden death and improves total survival in selected patient populations who have not previously had a cardiac arrest or sustained VT.Catheter ablation is now an important option to control recurrent VT.The field has evolved rapidly and is a work in progress.Ablation is often a sole therapy of VT in patients without structural heart disease and is commonly combined with an ICD and/or antiarrhythmic therapy for scar-related VT associated with structural heart disense.

abstracts@@ 室性心律失常(VA)是临床最常见的心律失常,包括室性早搏(PVC)、室性心动过速(VT)、心室扑动与颤动(VF).VA严重威胁人类的健康,尤其是发作时伴有血流动力学障碍的VT和VF,严重者甚至可危及患者生命.VA不仅可以发生于冠心病、非缺血性心肌病、致心律失常性右心室心肌病(ARVC)与心力衰竭等器质性心脏病患者,也可发生于无器质性心脏病患者,如原发性VA.近年来,一些遗传性VA如长QT综合征、短QT综合征、Brugada综合征和儿茶酚胺敏感性多形VT等,越来越受到电生理学者的关注.VA治疗是当今心血管领域研究的重点与热点.目前VA治疗措施主要包括抗心律失常药物(AADs)、植入型心律转复除颤器(ICD)和导管消融等.